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Consistent with our microarray data, we found a significant increase in the expression of Fasn , which encodes fatty acid synthetase, and Ppara , which encodes PPAR, the master transcriptional regulator for -oxidation, in adipocytes lacking GPR146 (Fig

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Further analysis revealed that the benefits of astaxanthin were more pronounced with aerobic exercise but were dose-dependent, with doses of 20 milligrams or more and supplementation for longer than 12 weeks providing the greatest benefit

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